Université Paris-Sud 11, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Châtenay-Malabry, France.
Org Biomol Chem. 2011 Sep 21;9(18):6200-4. doi: 10.1039/c1ob05664f. Epub 2011 Jul 28.
A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)(2) and Cs(2)CO(3) has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.
已经开发出一种在 Cu(acac)2 和 Cs2CO3 的存在下还原 N-对甲苯磺酰腙与胺的偶联的一般方法。该方案对于各种伯胺和仲胺、氨基醇以及唑衍生物非常有效且具有化学选择性，以高产率得到α-支链胺。
