Murakami K, Tamada T, Abe K, Nara M, Hisata S, Mitsuishi Y, Muramatsu S, Gomi K, Ebina M, Nukiwa T
Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sarcoidosis Vasc Diffuse Lung Dis. 2011 Jul;28(1):75-8.
Osseous sarcoidosis is relatively uncommon, and treatment with corticosteroids is not always effective. Moreover, patients with an advanced stage of pulmonary sarcoidosis are sometimes infected with aspergillus in the cavities of the pulmonary lesions, and long-term use of corticosteroids should be prohibited to prevent the development of fatal invasive pulmonary aspergillosis. Here, we described a unique case of osseous sarcoidosis with pulmonary aspergillosis, showing a rapid improvement of the osseous symptoms just after the administration of the antifungal agent, itraconazole. Itraconazole is likely to become a candidate among new therapeutic agents for osseous sarcoidosis.
骨结节病相对少见，使用皮质类固醇进行治疗并非总是有效。此外，晚期肺结节病患者有时会在肺部病变空洞中感染曲霉菌，应禁止长期使用皮质类固醇以预防致命性侵袭性肺曲霉菌病的发生。在此，我们描述了一例骨结节病合并肺曲霉菌病的独特病例，该病例显示在给予抗真菌药物伊曲康唑后，骨症状迅速改善。伊曲康唑可能会成为骨结节病新治疗药物的候选药物之一。
