Laboratory of Parasitic Diseases, NIAID, NIH, 4 Center Drive, Building 4, Room 126, Bethesda, MD 20892, USA.
Expert Rev Neurother. 2011 Aug;11(8):1175-83. doi: 10.1586/ern.11.86.
The cystic larvae of Taenia solium commonly infect the human nervous system, resulting in neurocysticercosis, a major contributor to seizure disorders in most of the world. Inflammation around the parasites is a hallmark of neurocysticercosis pathophysiology. Although mechanisms regulating this inflammation are poorly understood, anti-inflammatory drugs, particularly corticosteroids, have been long used alone or with anthelmintics to manage disease and limit neurological complications and perhaps damage to neural tissues. Only scarce controlled data exist to determine when and what type of corticosteroids and the treatment regime to use. This article revisits the mechanisms of action, rationale, evidence of benefit, safety and problems of corticosteroids in the context of neurocysticercosis, as well as alternative anti-inflammatory strategies to limit the damage caused by inflammation in the CNS.
猪带绦虫的囊尾蚴通常会感染人体神经系统，导致囊虫病，这是世界上大多数癫痫发作的主要原因。寄生虫周围的炎症是囊虫病病理生理学的一个标志。尽管调节这种炎症的机制还不清楚，但抗炎药物，特别是皮质类固醇，长期以来一直被单独使用或与驱虫药一起用于治疗疾病，以限制神经并发症并可能减轻对神经组织的损害。目前仅有少量对照数据可以确定何时以及使用哪种类型的皮质类固醇以及治疗方案。本文重新审视了皮质类固醇在囊虫病中的作用机制、原理、获益证据、安全性和问题，以及限制 CNS 炎症造成损害的替代抗炎策略。
