Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France, 15-20 rue Leblanc, 75 908 Paris Cedex 15, France.
Future Microbiol. 2011 Jul;6(7):731-7. doi: 10.2217/fmb.11.64.
Women are now becoming pivotal in the epidemiological spread of HIV infection throughout the world, especially in developing countries, where heterosexual transmission accounts for more than 80% of all new HIV infections. Recently, significant but partial successes have occurred in the field of HIV prevention, including male circumcision, preventive HIV vaccines, vaginal microbicides and oral pre-exposure prophylaxis, and there is increasingly widespread access to antiretroviral treatment. However, none of the currently available tools for HIV intervention are sufficiently effective, particularly for women, and all require further development. Among all biomedical approaches, microbicides could hold the greatest hope of curtailing AIDS worldwide, especially if used by women in Africa. Research for an efficacious microbicide constitutes a priority in the global agenda to prevent HIV infection. Finally, the combination of existing partially effective strategies for HIV prevention should be promoted, scaled-up and evaluated.
女性在全球范围内的 HIV 感染流行病学传播中起着至关重要的作用，尤其是在发展中国家，异性传播占所有新感染 HIV 病例的 80%以上。最近，HIV 预防领域取得了显著但部分成功，包括男性包皮环切术、预防性 HIV 疫苗、阴道杀菌剂和口服暴露前预防，以及越来越广泛地获得抗逆转录病毒治疗。然而，目前用于 HIV 干预的工具都没有足够有效，特别是对女性而言，并且都需要进一步开发。在所有的生物医学方法中，杀菌剂可能是全球范围内遏制艾滋病的最大希望，特别是如果非洲的女性使用的话。研究有效的杀菌剂是预防 HIV 感染全球议程中的一个优先事项。最后，应促进、扩大和评估现有部分有效的 HIV 预防策略的组合。
