Department of Pharmacology, University of Oxford, UK Department of Physiology, New York Medical College, Valhalla, New York, USA.
Br J Pharmacol. 2012 Feb;165(3):544-60. doi: 10.1111/j.1476-5381.2011.01606.x.
Obesity has detrimental effects on the microcirculation. Functional changes in microvascular responsiveness may increase the risk of developing cardiovascular complications in obese patients. Emerging evidence indicates that selective therapeutic targeting of the microvessels may prevent life-threatening obesity-related vascular complications, such as ischaemic heart disease, heart failure and hypertension. It is also plausible that alterations in adipose tissue microcirculation contribute to the development of obesity. Therefore, targeting adipose tissue arterioles could represent a novel approach to reducing obesity. This review aims to examine recent studies that have been focused on vasomotor dysfunction of resistance arteries in obese humans and animal models of obesity. Particularly, findings in coronary resistance arteries are contrasted to those obtained in other vascular beds. We provide examples of therapeutic attempts, such as use of statins, ACE inhibitors and insulin sensitizers to prevent obesity-related microvascular complications. We further identify some of the important challenges and opportunities going forward.
This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-3.
肥胖对微循环有不利影响。微血管反应性的功能变化可能会增加肥胖患者发生心血管并发症的风险。新出现的证据表明，选择性地针对微血管进行治疗可能预防危及生命的肥胖相关血管并发症，如缺血性心脏病、心力衰竭和高血压。脂肪组织微循环的改变也可能导致肥胖的发生。因此，靶向脂肪组织小动脉可能是减少肥胖的一种新方法。本综述旨在研究最近关注肥胖人群和肥胖动物模型阻力动脉血管舒缩功能障碍的研究。特别地，我们将冠状动脉阻力动脉的研究结果与其他血管床的研究结果进行对比。我们提供了一些治疗尝试的例子，如使用他汀类药物、ACE 抑制剂和胰岛素增敏剂来预防肥胖相关的微血管并发症。我们进一步确定了一些重要的挑战和机遇。
本文是脂肪和血管反应性专题的一部分。要查看该部分中的其他文章，请访问 http://dx.doi.org/10.1111/bph.2012.165.issue-3。
