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[Cutaneous complications after organ transplantation].[器官移植后的皮肤并发症]
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Kaposi's sarcoma and other rare skin cancers in organ transplant patients.器官移植患者中的卡波西肉瘤及其他罕见皮肤癌。
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Viral oncogenesis and its role in nonmelanoma skin cancer.病毒致癌作用及其在非黑素瘤皮肤癌中的作用。
Br J Dermatol. 2011 Jun;164(6):1201-13. doi: 10.1111/j.1365-2133.2011.10322.x. Epub 2011 May 13.
2
Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated.皮肤鳞状细胞癌微环境中的肿瘤相关巨噬细胞呈异质性激活。
J Invest Dermatol. 2011 Jun;131(6):1322-30. doi: 10.103/jid.2011.9. Epub 2011 Feb 10.
3
The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.人类皮肤鳞状细胞癌的微环境以淋巴管密度增加和巨噬细胞来源的 VEGF-C 表达增强为特征。
J Invest Dermatol. 2011 Jan;131(1):229-36. doi: 10.1038/jid.2010.266. Epub 2010 Sep 9.
4
Voriconazole exposure and geographic location are independent risk factors for squamous cell carcinoma of the skin among lung transplant recipients.伏立康唑暴露和地理位置是肺移植受者皮肤鳞状细胞癌的独立危险因素。
J Heart Lung Transplant. 2010 Nov;29(11):1240-4. doi: 10.1016/j.healun.2010.05.022. Epub 2010 Jun 29.
5
Squamous cell carcinoma of the skin shows a distinct microRNA profile modulated by UV radiation.皮肤鳞状细胞癌呈现出一种由紫外线辐射调节的独特微小RNA谱。
J Invest Dermatol. 2010 Nov;130(11):2686-9. doi: 10.1038/jid.2010.169. Epub 2010 Jun 24.
6
Catastrophic squamous cell carcinoma in lung transplant patients treated with voriconazole.接受伏立康唑治疗的肺移植患者发生的灾难性鳞状细胞癌。
Dermatol Surg. 2010 Nov;36(11):1752-5. doi: 10.1111/j.1524-4725.2010.01596.x.
7
Opposing roles for calcineurin and ATF3 in squamous skin cancer.钙调神经磷酸酶和活化转录因子3在鳞状皮肤癌中的相反作用。
Nature. 2010 May 20;465(7296):368-72. doi: 10.1038/nature08996.
8
X-linked chronic granulomatous disease with voriconazole-induced photosensitivity/ photoaging reaction.伴有伏立康唑诱导的光敏性/光老化反应的X连锁慢性肉芽肿病
J Drugs Dermatol. 2010 May;9(5):562-4.
9
Melanoma in solid organ transplant recipients.实体器官移植受者的黑色素瘤。
Am J Transplant. 2010 May;10(5):1297-304. doi: 10.1111/j.1600-6143.2010.03078.x. Epub 2010 Mar 26.
10
Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial.在长期接受肾移植的患者中转换为基于西罗莫司的免疫抑制方案:前瞻性、随机、评估者盲法、对照临床试验中(前)恶性肿瘤和非黑素瘤皮肤癌发生率降低。
Am J Transplant. 2010 Jun;10(6):1385-93. doi: 10.1111/j.1600-6143.2009.02997.x. Epub 2010 Feb 1.

移植受者中的皮肤癌,脱离险境。ITSCC 和 SCOPE 的科学务虚会。

Skin cancer in transplant recipients, out of the woods. Scientific retreat of the ITSCC and SCOPE.

机构信息

Department of Dermatology, Yale University School of Medicine, New Haven, CA, USA.

出版信息

Am J Transplant. 2011 Aug;11(8):1584-91. doi: 10.1111/j.1600-6143.2011.03645.x.

DOI:10.1111/j.1600-6143.2011.03645.x
PMID:21797972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3726269/
Abstract

The International Transplant Skin Cancer Collaborative (ITSCC) is an organization of more than 300 members dedicated to the study and care of skin changes that develop in solid-organ transplant recipients. This group of medical and surgical dermatologists, transplant surgeons and basic science researchers was formed to better understand the basic science of transplant dermatology, and to work collaboratively to address the clinical challenges in this patient population. Transplant patients have an ∼100-fold increased risk of developing cutaneous squamous cell carcinoma than the general population and are also at an increased risk of developing basal cell carcinoma, melanoma, Merkel cell carcinoma and Kaposi's sarcoma. In October 2010, ITSCC and its European counterpart Skin Care in Organ Transplant Patients Europe (SCOPE) held a joint biennial 4-day scientific retreat in the woods near Essex, Massachusetts. In this meeting report we provide an up-to-date distillation of the novel findings presented in the 21 oral abstracts, at the tumor board and within the working groups.

摘要

国际移植皮肤癌协作组织(ITSCC)是一个由 300 多名成员组成的组织,致力于研究和护理实体器官移植受者中出现的皮肤变化。这群医学和外科皮肤科医生、移植外科医生和基础科学研究人员的成立是为了更好地了解移植皮肤科的基础科学,并共同努力应对这一患者群体的临床挑战。与普通人群相比,移植患者罹患皮肤鳞状细胞癌的风险增加了约 100 倍,罹患基底细胞癌、黑色素瘤、默克尔细胞癌和卡波西肉瘤的风险也增加了。2010 年 10 月,ITSCC 及其欧洲对应组织“器官移植患者皮肤护理欧洲”(SCOPE)在马萨诸塞州埃塞克斯附近的树林中举行了一次联合两年一度的为期 4 天的科学务虚会。在这份会议报告中,我们提供了 21 个口头摘要、肿瘤委员会和工作组中提出的新发现的最新提炼。