Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, C/Irunlarrea s/n, Pamplona, Spain.
Br J Nutr. 2012 Feb;107(4):533-8. doi: 10.1017/S0007114511003424. Epub 2011 Jul 29.
The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts. This association appears to be dependent on dietary macronutrients. Therefore, the aim of the present study was to evaluate whether dietary fatty acid intake distribution could interact with this FTO genetic variation and obesity in a Spanish case-control study of children and adolescents. A total of 354 Spanish children and adolescents aged 6-18 years (49 % males) were genotyped for the rs9939609 variant of the FTO gene. Anthropometric parameters were taken and energy intake was measured. We observed an interaction between the consumption of SFA (percentage of total energy) and PUFA:SFA ratio and obesity risk linked to the rs9939609 SNP of the FTO gene. In the study population of the present study, the risk allele carriers consuming more than 12·6 % SFA (of total energy) had an increased obesity risk compared with TT carriers. In a similar way, A allele carriers with an intake ratio lower than 0·43 PUFA:SFA presented a higher obesity risk than TT subjects. In summary, the present study reports for the first time the influence of dietary fatty acid distribution on the effect of the rs9939609 polymorphism of the FTO gene on children and adolescents' obesity risk.
肥胖相关基因（FTO）的 rs9939609 多态性与多个欧洲队列的儿童肥胖症广泛相关。这种相关性似乎取决于饮食中的宏量营养素。因此，本研究旨在评估在西班牙儿童和青少年的病例对照研究中，饮食脂肪酸摄入量分布是否可以与这种 FTO 基因变异和肥胖相互作用。共对 354 名 6-18 岁的西班牙儿童和青少年（49%为男性）进行了 FTO 基因 rs9939609 变体的基因分型。测量了人体测量参数和能量摄入。我们观察到 SFA（总能量的百分比）和 PUFA:SFA 比值的消耗与 FTO 基因 rs9939609 SNP 与肥胖风险之间存在交互作用。在本研究的研究人群中，与 TT 携带者相比，摄入超过 12.6% SFA（总能量）的风险等位基因携带者肥胖风险增加。同样，摄入的 PUFA:SFA 比值低于 0.43 的 A 等位基因携带者肥胖风险高于 TT 受试者。总之，本研究首次报告了饮食脂肪酸分布对 FTO 基因 rs9939609 多态性对儿童和青少年肥胖风险影响的影响。
