Department of Clinical Nutrition, School of Nutrition and food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Lipids Health Dis. 2020 Aug 26;19(1):197. doi: 10.1186/s12944-020-01372-x.
Dietary macronutrients may indirectly affect body weight through their interactions with the fat mass and obesity associated (FTO) gene. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macronutrients intake in overweight adults.
This study was carried out on 196 overweight adults of Shiraz, Iran. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. The association between dietary macronutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, and the serum levels of triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL).
The higher intake of carbohydrates (P < 0.001), fat (P = 0.009), and calorie (P = 0.001) were significantly associated with rs9939609 AA genotype (P = 0.001). Carriers of the AA genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype after adjusting for age and sex (P = 0.019, P = 0.010 and P = 0.001, respectively). Further adjustments for physical activity, TG, LDL, and FBS did not change these results.
The amounts of dietary calorie, carbohydrate, and fat intake were associated with FTO genotype. Further studies are warranted to confirm these associations and to identify the underlying mechanisms.
宏量营养素可能通过与脂肪量和肥胖相关（FTO）基因的相互作用间接影响体重。本研究旨在探讨 FTO 基因 rs9939609 多态性与超重成年人宏量营养素摄入的关系。
本研究在伊朗设拉子的 196 名超重成年人中进行。使用经过验证的 168 项半定量食物频率问卷（FFQ）评估饮食摄入量。对 FTO 基因 rs9939609 多态性进行基因分型。在校正性别、年龄、体力活动以及甘油三酯、空腹血糖（FBS）和低密度脂蛋白（LDL）水平后，使用线性回归评估膳食宏量营养素与 FTO 基因型之间的关联。
碳水化合物（P<0.001）、脂肪（P=0.009）和卡路里（P=0.001）的摄入量较高与 rs9939609 AA 基因型显著相关（P=0.001）。在校正年龄和性别后，rs9939609 AA 基因型携带者的卡路里、脂肪和碳水化合物摄入量显著高于 TT 基因型携带者（P=0.019、P=0.010 和 P=0.001）。进一步调整体力活动、TG、LDL 和 FBS 并未改变这些结果。
膳食卡路里、碳水化合物和脂肪摄入量与 FTO 基因型有关。需要进一步的研究来证实这些关联，并确定潜在的机制。
