GABA 能突触发育中的新兴主题。
Emerging themes in GABAergic synapse development.
机构信息
Brandeis Univeristy, Department of Biology, National Center for Behavioral Genomics, Volen Center for Complex Systems, Waltham, MA 02453, USA.
出版信息
Prog Neurobiol. 2011 Sep 15;95(1):68-87. doi: 10.1016/j.pneurobio.2011.07.002. Epub 2011 Jul 20.
Abstract
Glutamatergic synapse development has been rigorously investigated for the past two decades at both the molecular and cell biological level yet a comparable intensity of investigation into the cellular and molecular mechanisms of GABAergic synapse development has been lacking until relatively recently. This review will provide a detailed overview of the current understanding of GABAergic synapse development with a particular emphasis on assembly of synaptic components, molecular mechanisms of synaptic development, and a subset of human disorders which manifest when GABAergic synapse development is disrupted. An unexpected and emerging theme from these studies is that glutamatergic and GABAergic synapse development share a number of overlapping molecular and cell biological mechanisms that will be emphasized in this review.
摘要
过去二十年来，人们在分子和细胞生物学水平上对谷氨酸能突触发育进行了深入研究，但直到最近，人们对 GABA 能突触发育的细胞和分子机制的研究才达到类似的强度。这篇综述将详细概述 GABA 能突触发育的当前认识，特别强调突触成分的组装、突触发育的分子机制以及 GABA 能突触发育受到干扰时表现出的一组人类疾病。这些研究中一个出人意料且正在浮现的主题是，谷氨酸能和 GABA 能突触发育共享许多重叠的分子和细胞生物学机制，本综述将重点介绍这些机制。
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