Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara, Italy.
Mitochondrion. 2012 Jan;12(1):77-85. doi: 10.1016/j.mito.2011.07.004. Epub 2011 Jul 21.
Mitochondria are crucial in different intracellular pathways of signal transduction. Mitochondria are capable of decoding a variety of extracellular stimuli into markedly different intracellular actions, ranging from energy production to cell death. The fine modulation of mitochondrial calcium (Ca(2+)) homeostasis plays a fundamental role in many of the processes involving this organelle. When mitochondrial Ca(2+) homeostasis is compromised, different pathological conditions can occur, depending on the cell type involved. Recent data have shed light on the molecular identity of the main proteins involved in the handling of mitochondrial Ca(2+) traffic, opening fascinating and ambitious new avenues for mitochondria-based pharmacological strategies.
线粒体在不同的细胞内信号转导途径中起着至关重要的作用。线粒体能够将各种细胞外刺激解码为明显不同的细胞内作用，从能量产生到细胞死亡。线粒体钙离子（Ca（2+））稳态的精细调节在涉及该细胞器的许多过程中起着基础性的作用。当线粒体 Ca（2+）稳态受到干扰时，不同的病理状况会发生，具体取决于所涉及的细胞类型。最近的数据揭示了参与线粒体 Ca（2+）流量处理的主要蛋白质的分子特征，为基于线粒体的药理学策略开辟了令人兴奋和雄心勃勃的新途径。
