Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria.
Diagnostic and Research Institute for Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria; Department of Health Sciences and Technology, ETH Zurich, Schorenstraße 16, 8603 Schwerzenbach, Switzerland.
Mitochondrion. 2020 Nov;55:164-173. doi: 10.1016/j.mito.2020.10.003. Epub 2020 Oct 15.
Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.
鉴于解偶联蛋白 2（UCP2）在健康和疾病中的多种功能，深入了解该蛋白在生理和病理生理条件下的分子作用是必不可少的。本综述旨在重新审视和阐明 UCP2 在线粒体中的基本分子功能，特别强调其在调节线粒体钙（Ca）摄取中的复杂作用。UCP2 对线粒体中各种重要过程的调节作用使其成为健康和疾病中线粒体动态平衡的关键调节剂。
