Cabbar Fatih, Güler Nurhan, Kürkcü Mehmet, Işeri Ufuk, Sençift Kemal
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
J Oral Maxillofac Surg. 2011 Oct;69(10):2537-47. doi: 10.1016/j.joms.2011.03.040. Epub 2011 Jul 27.
The purpose of this study was to compare Unilab Surgibone (USB) (Mississauga, Ontario, Canada), a bone xenograft (bovine), with platelet-rich plasma (PRP) and USB without PRP to augment the human maxillary sinus in preparation to receive dental implants.
Patients who had bilateral pneumatized maxillary sinuses were included. Sinuses on one side were augmented with the USB-PRP combination and formed the study group, whereas the opposite-side sinuses were augmented with USB alone and served as controls. Bone biopsy specimens were taken during implant placement at 6.8 ± 0.9 months after maxillary sinus floor augmentation. Resonance frequency analysis measurements were performed at implant placement (first control) and before the prosthetic stage (second control), at 6.5 ± 0.7 months after implant surgery.
There were 10 patients (7 men and 3 women; mean age, 53.7 ± 0.8 years). Integration between new bone and residual grafts was histologically observed in all samples. The volumes of soft tissue were 59.9% ± 7.5% and 57.8% ± 4.4% in the control and study groups, respectively; residual graft, 21.9% ± 6.6% and 23.6% ± 5.9%, respectively; new bone, 15.8% ± 4.8% and 16.0% ± 3.8%, respectively; and trabecular bone, 64.7% ± 22.5% and 69.1% ± 18.6%, respectively. A positive correlation was found between new bone volume and trabecular bone volume (P = .0001). The mean Implant Stability Quotient (ISQ) values were 71.7 ± 4.9 and 70.3 ± 5.7 in the control and study groups, respectively, at first control and 75.4 ± 6.4 and 74.4 ± 6.4, respectively, at second control. The mean ISQ values at second control in both groups were significantly higher than at first control (P = .043 and P = .028, respectively). No statistically significant differences were observed between groups (P > .05).
The combination of USB and PRP does not have any effect on new bone formation and implant stabilization.
本研究旨在比较一种骨异种移植物（牛源）Unilab Surgibone（USB，加拿大安大略省密西沙加市）联合富血小板血浆（PRP）与单纯USB用于上颌窦增量以准备植入牙种植体的效果。
纳入双侧上颌窦气化的患者。一侧上颌窦采用USB-PRP联合进行增量，形成研究组，而另一侧上颌窦仅采用USB进行增量，作为对照组。在上颌窦底增量后6.8±0.9个月植入种植体时获取骨活检标本。在种植体植入时（首次对照）以及种植体手术后6.5±0.7个月的修复阶段前（二次对照）进行共振频率分析测量。
共有10例患者（7例男性和3例女性；平均年龄53.7±0.8岁）。在所有样本中均通过组织学观察到新骨与残余移植物之间的融合。对照组和研究组的软组织体积分别为59.9%±7.5%和57.8%±4.4%；残余移植物分别为21.9%±6.6%和23.6%±5.9%；新骨分别为15.8%±4.8%和16.0%±3.8%；小梁骨分别为64.7%±22.5%和69.1%±18.6%。发现新骨体积与小梁骨体积之间存在正相关（P = .0001）。在首次对照时，对照组和研究组的平均种植体稳定性商数（ISQ）值分别为71.7±4.9和70.3±5.7，在二次对照时分别为75.4±6.4和74.4±6.4。两组在二次对照时的平均ISQ值均显著高于首次对照时（分别为P = .043和P = .028）。组间未观察到统计学上的显著差异（P > .05）。
USB与PRP联合对新骨形成和种植体稳定性无任何影响。
