Zhang Yinchun, Huang Lei, Hu Mina, Sun Fei, Zhu Qiuyan, Liu Chuanxia, Qiu Xiaoling
Shaoxing Stomatological Hospital, 312000 Shaoxing, Zhejiang, People's Republic of China.
Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, 510280 Guangzhou, Guangdong, People's Republic of China.
ACS Omega. 2025 Jul 2;10(27):28547-28566. doi: 10.1021/acsomega.5c01252. eCollection 2025 Jul 15.
Autologous blood-derived preparations are enriched with growth factors (GFs) important for bone regeneration; however, the cytokines in blood-derived preparations are often released in bursts. Electrospinning nanofibers can mimic the structure of the extracellular matrix (ECM) and promote cellular osteogenesis. In recent years, techniques for combining autologous blood-derirved preparations and electrospinning nanofibers have been developed with the aim of slowing down the release of cytokines from blood-derived preparations, decreasing the rate of degradation of the nanomaterials, and facilitating intracellular and extracellular exchange of substances to provide a favorable microenvironment for bone regeneration. We review the application of different autologous blood-derived preparations in bone defects, focusing on dental bone defects. And then we summarize the existing techniques for electrospinning nanofibers preparation, and emphasize the application of blood-derived preparations combined with electrospinning techniques in bone tissue engineering (BTE). This approach is expected to provide a basis for the development of this technology in dental bone regeneration and offer theoretical support for its realization in clinic.
自体血液衍生制剂富含对骨再生重要的生长因子（GFs）；然而，血液衍生制剂中的细胞因子通常会突然释放。静电纺丝纳米纤维可以模拟细胞外基质（ECM）的结构并促进细胞成骨。近年来，已开发出将自体血液衍生制剂与静电纺丝纳米纤维相结合的技术，目的是减缓血液衍生制剂中细胞因子的释放，降低纳米材料的降解速率，并促进细胞内外物质交换，为骨再生提供有利的微环境。我们综述了不同自体血液衍生制剂在骨缺损中的应用，重点关注牙骨缺损。然后我们总结了静电纺丝纳米纤维制备的现有技术，并强调了血液衍生制剂与静电纺丝技术相结合在骨组织工程（BTE）中的应用。这种方法有望为该技术在牙骨再生中的发展提供依据，并为其在临床中的实现提供理论支持。
