Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Early Hum Dev. 2011 Sep;87(9):611-8. doi: 10.1016/j.earlhumdev.2011.07.008. Epub 2011 Jul 27.
Congenital lung lesions, mostly congenital cystic adenomatoid malformations (CCAMs) and bronchopulmonary sequestrations (BPSs), are uncommon disorders. Prenatal intervention in severely affected (hydropic) fetuses has drastically improved perinatal survival. Not much is known, however, on the short-term and long-term respiratory and neurodevelopmental outcome. Several small case series have been reported and suggest an increased incidence of neonatal morbidity, mainly associated with prematurity and respiratory failure at birth. Overall, neonatal mortality and morbidity after prenatal interventions for CCAM seems to be worse than for BPS. This review focuses on the neonatal outcome after prenatal intervention for congenital lung lesions and summarizes the results reported in the literature.
先天性肺病变，主要为先天性囊性腺瘤样畸形（CCAMs）和支气管肺隔离症（BPSs），是罕见疾病。严重受影响（水肿）胎儿的产前干预极大地提高了围产期存活率。然而，对于短期和长期呼吸和神经发育结局知之甚少。已经报道了几个小的病例系列，并表明新生儿发病率增加，主要与早产和出生时呼吸衰竭有关。总体而言，CCAM 的产前干预后的新生儿死亡率和发病率似乎比 BPS 更差。这篇综述重点关注产前干预先天性肺病变的新生儿结局，并总结文献中的结果。
