多发性硬化症的治疗依从性。
Adherence to treatment in multiple sclerosis.
作者信息
Santolaya Perrín R, Fernández-Pacheco García Valdecasas M, Arteche Eguizabal L, Gema Pérez Pérez I, Muñoz Muñoz N, Ibarra Barrueta O, Callejón Callejón G
机构信息
Servicio de Farmacia, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
出版信息
Farm Hosp. 2012 May-Jun;36(3):124-9. doi: 10.1016/j.farma.2011.02.006. Epub 2011 Jul 28.
OBJECTIVE
To find out if patients with multiple sclerosis adhere to treatment with beta interferons and glatiramer acetate, the percentage of withdrawal and its causes.
METHODS
Observational, longitudinal, prospective, national, multicentre study which selected multiple sclerosis patients who attended the hospital pharmacy department to collect their medication. The main variable was the adherence percentage during a year, measured as the relationship between the dose of the dispensed and necessary drug. Treatment withdrawals and their causes were then measured.
RESULTS
Over a six-month period, 543 patients from 39 pharmacy departments were included. The average time exposed to the drugs during the study period was 312 days and the average adherence in this period was 61.5% (95% CI: 59.4-63.5). Thirty-four (6.26%) of the 543 study participants withdrew treatment, which for most cases was decided by the doctor.
CONCLUSIONS
Multiple sclerosis patients' treatment adherence during a period of one year has been lower than the ideal. The causes should therefore be analysed and corrective measures established.
目的
了解多发性硬化症患者是否坚持使用β-干扰素和醋酸格拉替雷治疗，停药率及其原因。
方法
进行一项观察性、纵向、前瞻性、全国性、多中心研究，选取到医院药房取药的多发性硬化症患者。主要变量是一年中的依从率，通过已配药剂量与所需药物剂量之间的关系来衡量。然后对停药情况及其原因进行评估。
结果
在六个月的时间里，纳入了来自39个药房的543名患者。研究期间患者平均用药时间为312天，这期间的平均依从率为61.5%（95%置信区间：59.4 - 63.5）。543名研究参与者中有34名（6.26%）停药，大多数情况下停药是由医生决定的。
结论
多发性硬化症患者一年期间的治疗依从率低于理想水平。因此，应分析原因并制定纠正措施。
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