Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.
Curr Opin Microbiol. 2011 Aug;14(4):470-5. doi: 10.1016/j.mib.2011.07.012. Epub 2011 Jul 27.
Dengue virus (DENV) is the causative agent of the most prevalent arthropod-borne viral disease, thus representing a significant global health burden. Because of its limited coding capacity, DENV exploits components and pathways of the host cell to assure productive replication. In the past few years, important insights into this intimate interaction between DENV and the host cell have been gained. These include the identification of the ER-associated degradation pathway, autophagy, the unfolded protein response or lipid droplets that all play a crucial role for efficient DENV replication. In addition, strategies used by the virus to combat innate antiviral responses have been unraveled. Improving our understanding of the DENV-host cell relation will facilitate our attempts to develop efficient antiviral strategies.
登革热病毒（DENV）是最常见的虫媒病毒病的病原体，因此是一个重大的全球健康负担。由于其有限的编码能力，DENV 利用宿主细胞的成分和途径来保证有效的复制。在过去的几年中，人们对 DENV 与宿主细胞之间的这种密切相互作用有了重要的了解。其中包括鉴定内质网相关降解途径、自噬、未折叠蛋白反应或脂滴，这些都对 DENV 的有效复制起着至关重要的作用。此外，病毒用来对抗先天抗病毒反应的策略也已被揭示。提高我们对 DENV-宿主细胞关系的理解将有助于我们尝试开发有效的抗病毒策略。
