The University of Texas at Houston Graduate School of Biomedical Sciences, 6767 Bertner Avenue, S3.8344, Houston, TX 77030, USA.
Phys Med Biol. 2011 Aug 21;56(16):5287-302. doi: 10.1088/0031-9155/56/16/014. Epub 2011 Jul 28.
Image guidance using implanted fiducial markers is commonly used to ensure accurate and reproducible target positioning in radiation therapy for prostate cancer. The ideal fiducial marker is clearly visible in kV imaging, does not perturb the therapeutic dose in the target volume and does not cause any artifacts on the CT images used for treatment planning. As yet, ideal markers that fully meet all three of these criteria have not been reported. In this study, 12 fiducial markers were evaluated for their potential clinical utility in proton radiation therapy for prostate cancer. In order to identify the good candidates, each fiducial was imaged using a CT scanner as well as a kV imaging system. Additionally, the dose perturbation caused by each fiducial was quantified using radiochromic film and a clinical proton beam. Based on the results, three fiducials were identified as good candidates for use in proton radiotherapy of prostate cancer.
在前列腺癌放射治疗中，使用植入式基准标记物进行图像引导已被广泛应用，以确保靶区定位的精确性和可重复性。理想的基准标记物在千伏成像中应清晰可见，不会对靶区的治疗剂量产生干扰，并且不会在用于治疗计划的 CT 图像上产生任何伪影。然而，目前尚未报道完全满足这三个标准的理想标记物。在这项研究中，评估了 12 个基准标记物在前列腺癌质子放射治疗中的潜在临床应用价值。为了确定哪些是较好的候选者，我们使用 CT 扫描仪和千伏成像系统对每个基准标记物进行了成像。此外，还使用放射色胶片和临床质子束对每个基准标记物所引起的剂量干扰进行了量化。基于这些结果，确定了三个基准标记物可作为前列腺癌质子放疗的良好候选物。
