Giacaman Paula, Martínez María José, Chnaiderman Jonas, Ampuero Sandra, Santander Ester, Ramis Claudia, Sazunic Ivo, Garmendia María Luisa, Gómez Orietta
Dermatology Department, Hospital San José, Santiago, Chile.
Indian J Sex Transm Dis AIDS. 2011 Jan;32(1):30-3. doi: 10.4103/0253-7184.81251.
To identify clinical parameters in association with human papilloma virus (HPV) genotypes and histopathology diagnosis in HIV-positive patients with external condylomata acuminata (ECA), 400 Chilean HIV-positive patients were included in the study. Forty-seven patients presented ECA. Clinical parameters and socio demographic data were recorded. Histopathology study and HPV linear array genotyping assay were performed. Intraepithelial neoplasia (IEN) grade 2 or 3 was found in 8.5% of patients, associated to HPV-16. Patients were mainly single, MSM, with history of sexually transmitted disease (STD), multiple sexual partners, receiving antiretroviral therapy and with recurrent lesions. All ECA were mainly perianal, grey or pink colored, exophytic with less than two years evolution. No clinical parameter could predict the development of high grade IEN in HIV patients with ECA. It seems necessary to perform biopsy and genotype all HIV positive patients with ECA.
为了确定与HIV阳性的尖锐湿疣（ECA）患者的人乳头瘤病毒（HPV）基因型和组织病理学诊断相关的临床参数，400名智利HIV阳性患者被纳入该研究。47名患者患有ECA。记录了临床参数和社会人口统计学数据。进行了组织病理学研究和HPV线性阵列基因分型检测。8.5%的患者发现有2级或3级上皮内瘤变（IEN），与HPV-16相关。患者主要为单身、男男性行为者，有性传播疾病（STD）史、多个性伴侣，接受抗逆转录病毒治疗且有复发性病变。所有ECA主要位于肛周，呈灰色或粉红色，外生性，病程少于两年。没有临床参数能够预测HIV阳性的ECA患者发生高级别IEN。似乎有必要对所有HIV阳性的ECA患者进行活检和基因分型。
