World J Gastroenterol. 2011 Jul 7;17(25):2981-6. doi: 10.3748/wjg.v17.i25.2981.
The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the epithelium. On the one hand, age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation, which results in epithelial damage. On the other hand, the altered migration and function of regenerative stem cells, the age-related methylation of mucosal healing-associated genes, together with the alterations of growth factor signaling with age, may be involved in delayed mucosal regeneration. The connections of these alterations to the process of ageing are not fully known. The understanding and custom-tailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic strategies. Here, we aim to summarize the age-related microscopic and molecular changes of the human colon, as well as their role in altered mucosal healing.
随着年龄的增长，人类结肠中发生的生理和病理细胞及分子变化既影响导致黏膜损伤的炎症过程，也影响上皮的再生能力。一方面，与年龄相关的端粒缩短和炎症衰老可能导致结肠炎症的发展，从而导致上皮损伤。另一方面，再生干细胞迁移和功能的改变、与黏膜愈合相关基因的年龄相关甲基化，以及生长因子信号随年龄的改变，可能与黏膜再生延迟有关。这些变化与衰老过程的联系尚不完全清楚。了解和有针对性地修饰这些机制对于疾病预防和现代治疗策略具有重要的临床意义。在这里，我们旨在总结人类结肠与年龄相关的微观和分子变化及其在改变的黏膜愈合中的作用。
