Roane D S, Martin R J
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Pharmacol Biochem Behav. 1990 Jan;35(1):225-9. doi: 10.1016/0091-3057(90)90230-f.
Although an opioid-mediated mechanism appears to be involved in the alteration of pain perception during feeding behavior, little is known about macronutrient effects on nociception. In this report we show that prolonged sucrose feeding alters responsiveness to painful stimuli and the analgesic potency of morphine. Male Sprague-Dawley rats maintained on ad lib laboratory chow with continuous access to a 20% sucrose solution displayed a significant decrease in tail-flick latency as early as 20 hours after introduction of the sucrose. The differences in pain threshold were naloxone sensitive. After 25 days on the diet, morphine sulfate, 8 mg/kg administered IP, proved to be significantly more potent in the sucrose-fed animals. The results indicate that sucrose feeding alters endogenous opioid-mediated nociception.
尽管阿片类药物介导的机制似乎参与了进食行为期间疼痛感知的改变，但关于常量营养素对伤害感受的影响却知之甚少。在本报告中，我们表明长期摄入蔗糖会改变对疼痛刺激的反应以及吗啡的镇痛效力。自由采食实验室普通饲料并持续饮用20%蔗糖溶液的雄性Sprague-Dawley大鼠，在引入蔗糖后最早20小时，甩尾潜伏期就出现了显著缩短。疼痛阈值的差异对纳洛酮敏感。在饮食25天后，腹腔注射8mg/kg硫酸吗啡，结果证明在摄入蔗糖的动物中效力显著更高。结果表明，摄入蔗糖会改变内源性阿片类药物介导的伤害感受。
