Department of Biomedical Engineering, Boston University, 44 Cummington St., Boston, Massachusetts 02215, USA.
Biomicrofluidics. 2011 Jun;5(2):22201. doi: 10.1063/1.3576926. Epub 2011 Jun 29.
This study determines the optimal vascular designs for perfusing engineered tissues. Here, "optimal" describes a geometry that minimizes vascular volume fraction (the fractional volume of a tissue that is occupied by vessels) while maintaining oxygen concentration above a set threshold throughout the tissue. Computational modeling showed that optimal geometries depended on parameters that affected vascular fluid transport and oxygen consumption. Approximate analytical expressions predicted optima that agreed well with the results of modeling. Our results suggest one basis for comparing the effectiveness of designs for microvascular tissue engineering.
本研究旨在确定用于灌注工程组织的最佳血管设计。这里，“最佳”描述了一种几何形状，其特征在于血管体积分数最小化（组织中由血管占据的部分体积），同时保持整个组织中的氧浓度高于设定的阈值。计算模型表明，最佳几何形状取决于影响血管流体传输和氧气消耗的参数。近似解析表达式预测了与模型结果吻合良好的最优值。我们的研究结果为比较微血管组织工程设计的有效性提供了一个依据。
