使用扰动剂对大分子水凝胶进行键合
Bonding of macromolecular hydrogels using perturbants.
作者信息
Price Gavrielle M, Chu Kengyeh K, Truslow James G, Tang-Schomer Min D, Golden Andrew P, Mertz Jerome, Tien Joe
机构信息
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA.
出版信息
J Am Chem Soc. 2008 May 28;130(21):6664-5. doi: 10.1021/ja711340d. Epub 2008 May 3.
Abstract
This work describes a method to bond patterned macromolecular gels into monolithic structures using perturbants. Bonding strengths for a variety of solutes follow a Hofmeister ordering; this result and optical measurements indicate that bonding occurs by reversible perturbation of contacting gels. The resulting microfluidic gels are mechanically robust and can serve as scaffolds for cell culture.
摘要
这项工作描述了一种使用扰动剂将图案化的大分子凝胶粘结成整体结构的方法。多种溶质的粘结强度遵循霍夫迈斯特序列；这一结果和光学测量表明，粘结是通过接触凝胶的可逆扰动发生的。由此产生的微流控凝胶具有机械稳定性，可作为细胞培养的支架。
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