通过 Cu(I)/TF-BiphamPhos 催化的不对称 1,3-偶极环加成反应高效构建螺环色满-吡咯烷。
Highly efficient construction of spirocyclic chromanone-pyrrolidines via Cu(I)/TF-BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition.
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
出版信息
Chem Commun (Camb). 2011 Sep 14;47(34):9600-2. doi: 10.1039/c1cc13554f. Epub 2011 Jul 29.
PMID:21799997
Abstract
A facile synthesis of highly functional spiro-[4-chromanone-3,3'-pyrrolidine] bearing one unique spiro quarternary and three tertiary stereogenic centers is developed in excellent stereoselectivity for the first time.
摘要
首次发展了一种高立体选择性地合成具有一个独特的螺季碳和三个三级手性中心的高度官能化螺-[4-色满酮-3,3'-吡咯烷]的简便方法。
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