[多药耐药相关蛋白及其在多药耐药中的作用]
[Multidrug resistance-associated proteins and their roles in multidrug resistance].
作者信息
Zhang Hui, Fu Li-wu
机构信息
State Key Laboratory of Oncology in South China, Cancer Center Sun Yat-sen University, Guangzhou 510060, China.
出版信息
Yao Xue Xue Bao. 2011 May;46(5):479-86.
PMID:21800532
Abstract
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps. In this paper, physiological characteristics, structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed.
摘要
多药耐药性（MDR）是癌症化疗成功的主要障碍。多药耐药相关蛋白（MRP）在MDR过程中起重要作用。作为ATP结合盒（ABC）转运蛋白超家族，MRP是选择性和特异性的药物外排泵。本文综述了MRP的生理特性、结构特性、耐药谱以及相关的逆转研究。
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