Huang Wen-Jie, Ruan Shuai, Wen Fang, Lu Xiao-Na, Gu Su-Ping, Chen Xiao-Xue, Liu Miao, Shu Peng
Oncology Department, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Cancer Manag Res. 2020 Dec 2;12:12385-12394. doi: 10.2147/CMAR.S274599. eCollection 2020.
Chemotherapy is the main clinical treatment method of gastric cancer. Multidrug resistance (MDR) has become a common phenomenon with the development of tumors, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of survival rate of advanced gastric cancer. Therefore, the exploration of MDR reversal agents for gastric cancer is the focus and also the difficulty of current treatment. Currently, the researches on the mechanisms of drug resistance in gastric cancer have been continuously deepened, which reveal different pathways and targets of MDR, laying a solid foundation for studying reversal agents. As a kind of natural medicine, traditional Chinese medicine (TCM) owns the characteristics of low toxicity, high safety and effectiveness. It can inhibit the occurrence, growth and metastasis of tumors, and reverse MDR via multiple pathways and mechanisms, the pathological function of which has become a research hotspot in recent years. TCM reversers are mainly divided into Chinese medicine monomers, Chinese patent medicines, and Chinese herbal compounds. With certain quantity and advantage, TCM reversers for MDR play an important role in the clinical treatment and show great potential in gastric cancer.
化疗是胃癌的主要临床治疗方法。随着肿瘤的发展，多药耐药（MDR）已成为一种普遍现象，这降低了化疗效果，并使得突破晚期胃癌生存率的瓶颈变得困难。因此，探索胃癌多药耐药逆转剂是当前治疗的重点，也是难点。目前，对胃癌耐药机制的研究不断深入，揭示了多药耐药的不同途径和靶点，为研究逆转剂奠定了坚实基础。中药作为一种天然药物，具有低毒、高安全性和有效性的特点。它可以抑制肿瘤的发生、生长和转移，并通过多种途径和机制逆转多药耐药，其病理作用已成为近年来的研究热点。中药逆转剂主要分为中药单体、中成药和中药复方。具有一定数量和优势的多药耐药中药逆转剂在临床治疗中发挥着重要作用，在胃癌治疗中显示出巨大潜力。
