School of Polymers and High Performance Materials, Shelby F. Thames Polymer Science Research Center, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA.
Langmuir. 2011 Sep 6;27(17):11106-10. doi: 10.1021/la201957a. Epub 2011 Aug 9.
These studies demonstrate a new approach of producing multifunctionalized coatings on poly(tetrafluoroethylene) (PTFE) surfaces by covalent attachments of multilayers (CAM) of heparin (HP) and poly(ethylene glycol) (PEG). This process can be universally applied to other covalently bonded species and was facilitated by microwave plasma reactions in the presence of maleic anhydride which, upon ring-opening and hydrolysis, provided covalent attachment of COOH groups to PTFE. These studies showed that alternating layers of PEG and HP can be covalently attached to COOH-PTFE surfaces, and the volume concentration and surface density of PEG and HP on the PTFE surface achieved by the CAM were 7.02-6.04 × 10(-3) g/cm(3) (2.1-1.8 × 10(-7) g/cm(2)) and 9.3-8.7 × 10(-3) g/cm(3) (2.8-2.6 × 10(-7) g/cm(2)), respectively. The CAM process may serve numerous applications when the covalent modification of inert polymeric substrates is required and particularly where the presence of bioactive species for biocompatibility enhancement is desirable.
这些研究表明，通过肝素（HP）和聚乙二醇（PEG）的多层（CAM）的共价附着，可以在聚四氟乙烯（PTFE）表面上生产多功能化涂层的新方法。该过程可以普遍应用于其他共价键合的物质，并通过马来酸酐存在下的微波等离子体反应来促进，马来酸酐在开环和水解后，将 COOH 基团共价附着到 PTFE 上。这些研究表明，PEG 和 HP 的交替层可以共价附着到 COOH-PTFE 表面上，并且通过 CAM 实现的 PTFE 表面上的 PEG 和 HP 的体积浓度和表面密度分别为 7.02-6.04×10(-3) g/cm(3)（2.1-1.8×10(-7) g/cm(2))和 9.3-8.7×10(-3) g/cm(3)（2.8-2.6×10(-7) g/cm(2))。当需要惰性聚合物基质的共价修饰时，CAM 过程可能具有多种应用，特别是当需要存在生物活性物质以增强生物相容性时。
