Department of Biochemical Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
J Agric Food Chem. 2011 Sep 14;59(17):9150-7. doi: 10.1021/jf201640j. Epub 2011 Aug 9.
This experiment established the ovariectomized (OVX) rat model of postmenopausal osteoporosis and examined the effect of the oral administration of different dosages of dioscorea, red mold dioscorea (RMD), and soy isoflavones on bone mineral density (BMD). Three months after osteoporosis had been induced and 4 weeks after feeding had begun, the tibia and femur BMD of OVX rats administered RMD showed significant increases compared with that of all other groups of OVX rats. Closer examination using microcomputed tomography also revealed that the RMD-administered rats had denser trabecular bone volume and a higher trabecular number compared to all other rat groups. Reconstructed 3D imaging indicated increases in cancellous bone mineral content, cancellous bone mineral density, and cortical bone mineral content of the proximal tibia in OVX rats. These findings indicate that administration of monacolin K and phytoestrogen diosgenin could prevent bone loss induced by estrogen deficiency.
本实验建立了绝经后骨质疏松症去卵巢大鼠模型，考察了不同剂量的薯蓣、红曲薯蓣（RMD）和大豆异黄酮经口给药对骨密度（BMD）的影响。骨质疏松症诱导 3 个月后，开始给药 4 周后，与其他去卵巢大鼠组相比，给予 RMD 的去卵巢大鼠的胫骨和股骨 BMD 明显增加。使用微计算机断层扫描进一步检查发现，与其他所有大鼠组相比，给予 RMD 的大鼠的小梁骨体积更密集，小梁骨数量更高。重建的 3D 成像表明，去卵巢大鼠的胫骨近端的松质骨矿物质含量、松质骨矿物质密度和皮质骨矿物质含量增加。这些发现表明，给予洛伐他汀和植物雌激素薯蓣皂素可预防雌激素缺乏引起的骨丢失。
