Chabre M
Institut de Pharmacologie Moléculaire et Cellulaire du CNRS, Valbonne, France.
Trends Biochem Sci. 1990 Jan;15(1):6-10. doi: 10.1016/0968-0004(90)90117-t.
The action of fluoride ions on G proteins as well as on various ATPases and phosphatases, is related to their complexation with traces of aluminium or beryllium. These fluorometallic complexes act as analogs of phosphate: they bind with high affinity, but reversibly, in phosphate sites or, concomitantly with nucleoside-diphosphate, in nucleoside-triphosphate sites. The beryllofluoride complexes are strictly tetrahedral; they cannot take on the pentavalent conformation adopted by phosphate in transition states hence they interfere with phospho-transfer reaction mechanisms.
氟离子对G蛋白以及各种ATP酶和磷酸酶的作用，与其与痕量铝或铍的络合有关。这些氟金属络合物可作为磷酸盐的类似物：它们以高亲和力但可逆地结合在磷酸盐位点，或者与核苷二磷酸一起，结合在核苷三磷酸位点。铍氟络合物严格呈四面体结构；它们无法呈现磷酸盐在过渡态时所采用的五价构象，因此会干扰磷酸转移反应机制。
