National Virus Reference Laboratory-University College Dublin, Dublin, Ireland.
Emerg Infect Dis. 2011 Aug;17(8):1402-8. doi: 10.3201/eid1708.101760.
Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
人腺病毒（HAdV）血清型 14 很少被鉴定到。然而，一种新兴的变异体，称为 HAdV-14p1，最近在美国与急性呼吸道疾病爆发有关，其发病率和死亡率很高。我们回顾性分析了 2009 年 7 月 1 日至 2010 年 7 月 31 日期间通过免疫荧光、病毒培养或实时 PCR 确认为 HAdV 阳性的标本，并描述了 9 例 HAdV-14p1 感染病例，其纤维和 E1A 基因中存在特征性突变，与之前在美国检测到的病毒在系统发育上无法区分。3 名患者死亡；2 名患者免疫功能低下，1 名患者为免疫功能正常的成年人。我们建议增加对 HAdV-14p1 的监测，并建议在病因不明的突发急性呼吸道疾病，特别是致命感染的鉴别诊断中考虑该病毒。
