National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan.
PLoS One. 2013 Sep 20;8(9):e75208. doi: 10.1371/journal.pone.0075208. eCollection 2013.
Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan.
To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the past decade.
One hundred and twenty-six human adenoviruses, isolated between 2002 to 2011, were characterized via DNA sequencing of the hexon and fiber genes. The nucleotide sequences were then compared by phylogenetic analysis.
HAdV-B3 accounted for 64.3% (81/126) and peaked almost every year, whereas the sequences of hexon and fiber genes of HAdV-B3 were highly conserved in different years. A high incidence of co-infection of adenoviruses was observed (19.0%, 24/126); HAdV-B3 co-infected with HAdV-C2 was the most common combination (58.3%, 14/24). An additional interesting finding of repeated infection was noted in 10 children, all of whom showed first infection with adenovirus species HAdV-C, followed by species HAdV-B or HAdV-E.
HAdV-B3 was the predominant type of respiratory adenovirus circulating in Taiwan over the past ten years. This merits further attention for vaccine development. Furthermore, the observed high-incidence of adenoviral co-infections along with repeated infections found in our study provides important epidemiological insights into adenovirus infections.
腺病毒（HAdV）引起的呼吸道感染全年都很常见。最近，台湾观察到腺病毒感染显著增加。
了解过去十年台湾流行的呼吸道腺病毒的流行情况和分子流行病学。
对 2002 年至 2011 年间分离的 126 株人腺病毒进行 DNA 测序，以鉴定其六邻体和纤维基因。然后通过系统发育分析比较核苷酸序列。
HAdV-B3 占 64.3%（81/126），几乎每年都达到高峰，而 HAdV-B3 的六邻体和纤维基因序列在不同年份高度保守。观察到腺病毒的高合并感染率（19.0%，24/126）；HAdV-B3 与 HAdV-C2 的合并感染最为常见（58.3%，14/24）。在 10 名儿童中注意到了重复感染的有趣发现，他们均先感染腺病毒 HAdV-C，随后感染 HAdV-B 或 HAdV-E。
在过去十年中，HAdV-B3 是台湾流行的主要呼吸道腺病毒。这值得进一步关注疫苗开发。此外，我们的研究中观察到的腺病毒合并感染发生率高和重复感染情况为腺病毒感染提供了重要的流行病学见解。
