Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Emerg Infect Dis. 2011 Aug;17(8):1430-5. doi: 10.3201/eid1708.101328.
Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5' nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.
肠道病毒 68 型（EV68）是一种罕见的与呼吸道疾病相关的肠道病毒，与其他肠道病毒不同，它仅从呼吸道标本中被发现。我们从菲律宾莱特岛因严重肺炎住院的儿童的呼吸道标本中鉴定出 EV68。21 个样本通过 5'非翻译区测序显示与 EV68 具有高度相似性；其中 17 个样本通过病毒蛋白 1 衣壳编码区测序被确认为 EV68。此前报道的大多数 EV68 病例均为散发病例。我们鉴定出的所有 21 例患者均病情严重，2 例死亡，这可能是首例与 EV68 感染相关的致死病例。我们的研究表明，EV68 可能是严重呼吸道疾病的潜在致病因素。
