Department of Comparative Medicine, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
J. Craig Venter Institute, La Jolla, California, USA.
J Virol. 2022 Aug 10;96(15):e0083322. doi: 10.1128/jvi.00833-22. Epub 2022 Jul 19.
Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there is a paucity of data related to the virus and host-specific factors that predict disease severity and progression to the neurologic syndrome. EV-D68 infection of various animal models has served as an important platform for characterization and comparison of disease pathogenesis between historic and contemporary isolates. Still, there are significant gaps in our knowledge of EV-D68 pathogenesis that constrain the development and evaluation of targeted vaccines and antiviral therapies. Continued refinement and characterization of animal models that faithfully reproduce key elements of EV-D68 infection and disease is essential for ensuring public health preparedness for future EV-D68 outbreaks.
人肠道病毒 D68（EV-D68）是一种在全球重新出现的呼吸道病原体，与儿童急性弛缓性脊髓炎（AFM）的发生有关。目前，尚无针对 EV-D68 感染的批准疫苗或治疗方法，并且与病毒和宿主特异性因素相关的数据很少，这些因素可预测疾病的严重程度和向神经综合征的进展。各种动物模型中的 EV-D68 感染已成为用于比较和描述历史和现代分离株之间疾病发病机制的重要平台。但是，我们对 EV-D68 发病机制的认识仍然存在很大差距，这限制了针对疫苗和抗病毒疗法的开发和评估。持续改进和鉴定能够真实再现 EV-D68 感染和疾病关键要素的动物模型，对于确保为未来的 EV-D68 爆发做好公共卫生准备至关重要。
