Kore A M
Department of Veterinary Biosciences, University of Illinois, Urbana-Champaign College of Veterinary Medicine.
Vet Clin North Am Small Anim Pract. 1990 Mar;20(2):419-30. doi: 10.1016/s0195-5616(90)50036-4.
Nonsteroidal antiinflammatory drugs (NSAIDs) constitute a class of pharmacologically active agents with similar therapeutic actions and side effects, despite diverse chemical structures. NSAIDs inhibit the enzyme cyclo-oxygenase and, thus, decrease inflammation mediated by prostaglandins. Toxicoses due to NSAIDs are manifested primarily by gastrointestinal upset and hemorrhage and by renal damage. Management consists of detoxification measures, in addition to supportive and symptomatic care. The article outlines the incidence, clinical toxicity, mode of action, and pharmacokinetics of nonsteroidal antiinflammatory drugs. The toxic effects of NSAIDs on individual organ systems are described, and general management recommendations for the treatment of NSAID toxicoses are presented.
非甾体抗炎药（NSAIDs）是一类药理活性剂，尽管化学结构各异，但具有相似的治疗作用和副作用。NSAIDs抑制环氧化酶，从而减少前列腺素介导的炎症。NSAIDs引起的中毒主要表现为胃肠道不适、出血和肾损伤。处理方法包括解毒措施以及支持性和对症治疗。本文概述了非甾体抗炎药的发病率、临床毒性、作用方式和药代动力学。描述了NSAIDs对各个器官系统的毒性作用，并给出了治疗NSAIDs中毒的一般处理建议。
