Hennet Philippe R, Camy Guy A L, McGahie David M, Albouy Maxime V
Clinique vétérinaire ADVETIA, Paris, France.
J Feline Med Surg. 2011 Aug;13(8):577-87. doi: 10.1016/j.jfms.2011.05.012.
Chronic caudal stomatitis with alveolar/buccal mucositis in calicivirus-positive cats is the most severe presentation of feline chronic gingivostomatitis. Refractory cases are helped by antibiotic and anti-inflammatory treatments often including glucocorticoids. In order to evaluate the comparative efficacy of oromucosal administration of recombinant feline interferon omega (rFeIFN-ω) versus oral administration of glucocorticoids, a randomised, multi-centre, controlled, double-blind study was performed in 39 cats. The progression of behavioural, clinical and lesional scores was assessed over 90 days. Daily oromucosal treatment with 0.1 MU of rFeIFN-ω was associated with a significant improvement of clinical lesions (caudal stomatitis and alveolar/buccal mucositis) and a decrease of pain scores from D0 to D90. Although no such statistical improvement was noticed in the prednisolone group, there was, however, no significant difference between the two groups for most of the parameters, except pain at D60 and D90.
杯状病毒阳性猫的慢性尾口炎伴牙槽/颊部粘膜炎是猫慢性龈口炎最严重的表现形式。难治性病例通常采用包括糖皮质激素在内的抗生素和抗炎治疗。为了评估重组猫ω干扰素（rFeIFN-ω）口腔粘膜给药与口服糖皮质激素的相对疗效，对39只猫进行了一项随机、多中心、对照、双盲研究。在90天内评估行为、临床和病变评分的进展。每天用0.1 MU的rFeIFN-ω进行口腔粘膜治疗，可使临床病变（尾口炎和牙槽/颊部粘膜炎）显著改善，疼痛评分从第0天到第90天降低。虽然泼尼松龙组未观察到这种统计学上的改善，但除了第60天和第90天的疼痛外，两组在大多数参数上没有显著差异。
