University of Louisville, Department of Pathology, Louisville, KY 40202, USA.
Carbohydr Res. 2011 Oct 18;346(14):2213-21. doi: 10.1016/j.carres.2011.06.020. Epub 2011 Jun 29.
(1→3)-β-D-Glucans are well-established natural biological immunomodulators. However, problems inherited with the natural origin of these polysaccharides bring about significant setbacks, including batch-to-batch heterogeneity and significant differences based on the source and isolation techniques. In this study, we tried to overcome these problems by preparation of a quantitatively new set of oligo-(1→3)-β-D-glucan-based synthetic immunomodulators. Some of these non-natural oligosaccharides showed biological activities, such as stimulation of phagocytosis, modulation of gene expression, and anti-cancer activity, which were superior to natural glucans.
(1→3)-β-D-葡聚糖是成熟的天然生物免疫调节剂。然而，这些多糖的天然来源所带来的问题，包括批次间的异质性和基于来源和分离技术的显著差异，给它们的应用带来了重大阻碍。在本研究中，我们尝试通过制备一组全新的寡-(1→3)-β-D-葡聚糖类合成免疫调节剂来克服这些问题。其中一些非天然的寡糖表现出了生物活性，如刺激吞噬作用、调节基因表达和抗癌活性，这些活性优于天然葡聚糖。
