Legentil Laurent, Paris Franck, Ballet Caroline, Trouvelot Sophie, Daire Xavier, Vetvicka Vaclav, Ferrières Vincent
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France.
Université européenne de Bretagne, F-35000 Rennes, France.
Molecules. 2015 May 27;20(6):9745-66. doi: 10.3390/molecules20069745.
β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(1→3)-glucans can trigger different immune responses and act as efficient immunostimulating agents. They constitute prevalent sources of carbons for microorganisms after subsequent recognition by digesting enzymes. Nevertheless, mechanisms associated with both roles are not yet clearly understood. This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.
β-（1→3）-葡聚糖作为结构多糖存在于谷物、藻类中，或作为蘑菇或真菌表面分泌的胞外多糖。目前的研究已证实，β-（1→3）-葡聚糖可引发不同的免疫反应，并作为有效的免疫刺激剂发挥作用。在被消化酶识别后，它们构成了微生物普遍的碳源。然而，与这两种作用相关的机制尚未完全明确。本综述重点关注了已阐明的涉及这些天然或合成多糖及其受体（即，树突状细胞相关C型凝集素-1、补体受体3、糖脂、朗格汉斯蛋白和碳水化合物结合模块）的各种分子相互作用。
