Department of Hematology, TianJin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China.
Leuk Res. 2012 Mar;36(3):281-6. doi: 10.1016/j.leukres.2011.06.017. Epub 2011 Jul 28.
To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression on CD34+ cell than low-grade MDS and the control. It was suggested that the SDF-1/CXCR4 axis play an important role in MDS. Apoptosis was significantly increased in low-grade MDS, compared with high-grade MDS. The expression of VEGF and MVD were higher in the high-grade MDS than in the low-grade MDS. There are positive correlations between SDF-1 and apoptosis in the low-grade MDS. For the high-grade MDS, there were positive correlations between CXCR4 and VEGF, and between SDF-1 concentration and MVD. The apoptosis is one of the hallmarks for low-grade MDS and the angiogenesis for high-grade MDS. A refined understanding of the roles that SDF-1/CXCR4 axis and its correlation with angiogenesis and apoptosis play in MDS will fuel the development of therapies that can be targeted to the SDF-1/CXCR4 axis.
为了研究 SDF-1/CXCR4 轴在 MDS 中的作用，检测了 MDS 中 SDF-1 和 CXCR4、VEGF、MVD 和凋亡的表达。结果表明，低级别 MDS 的 SDF-1 表达高于高级别 MDS 和对照组。高级别 MDS 的 CD34+细胞上的 CXCR4 表达明显高于低级别 MDS 和对照组。表明 SDF-1/CXCR4 轴在 MDS 中发挥重要作用。低级别 MDS 中凋亡明显增加，与高级别 MDS 相比。高级别 MDS 中 VEGF 和 MVD 的表达高于低级别 MDS。低级别 MDS 中 SDF-1 与凋亡呈正相关。对于高级别 MDS，CXCR4 与 VEGF 之间以及 SDF-1 浓度与 MVD 之间存在正相关。凋亡是低级别 MDS 的标志之一，血管生成是高级别 MDS 的标志之一。深入了解 SDF-1/CXCR4 轴及其与血管生成和凋亡的相关性在 MDS 中的作用，将推动针对 SDF-1/CXCR4 轴的治疗方法的发展。
