基质细胞衍生因子-1/CXCR4 轴在骨髓增生异常综合征中的作用：与血管生成和凋亡的相关性。
SDF-1/CXCR4 axis in myelodysplastic syndromes: correlation with angiogenesis and apoptosis.
机构信息
Department of Hematology, TianJin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China.
出版信息
Leuk Res. 2012 Mar;36(3):281-6. doi: 10.1016/j.leukres.2011.06.017. Epub 2011 Jul 28.
To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression on CD34+ cell than low-grade MDS and the control. It was suggested that the SDF-1/CXCR4 axis play an important role in MDS. Apoptosis was significantly increased in low-grade MDS, compared with high-grade MDS. The expression of VEGF and MVD were higher in the high-grade MDS than in the low-grade MDS. There are positive correlations between SDF-1 and apoptosis in the low-grade MDS. For the high-grade MDS, there were positive correlations between CXCR4 and VEGF, and between SDF-1 concentration and MVD. The apoptosis is one of the hallmarks for low-grade MDS and the angiogenesis for high-grade MDS. A refined understanding of the roles that SDF-1/CXCR4 axis and its correlation with angiogenesis and apoptosis play in MDS will fuel the development of therapies that can be targeted to the SDF-1/CXCR4 axis.
为了研究 SDF-1/CXCR4 轴在 MDS 中的作用，检测了 MDS 中 SDF-1 和 CXCR4、VEGF、MVD 和凋亡的表达。结果表明，低级别 MDS 的 SDF-1 表达高于高级别 MDS 和对照组。高级别 MDS 的 CD34+细胞上的 CXCR4 表达明显高于低级别 MDS 和对照组。表明 SDF-1/CXCR4 轴在 MDS 中发挥重要作用。低级别 MDS 中凋亡明显增加，与高级别 MDS 相比。高级别 MDS 中 VEGF 和 MVD 的表达高于低级别 MDS。低级别 MDS 中 SDF-1 与凋亡呈正相关。对于高级别 MDS，CXCR4 与 VEGF 之间以及 SDF-1 浓度与 MVD 之间存在正相关。凋亡是低级别 MDS 的标志之一，血管生成是高级别 MDS 的标志之一。深入了解 SDF-1/CXCR4 轴及其与血管生成和凋亡的相关性在 MDS 中的作用，将推动针对 SDF-1/CXCR4 轴的治疗方法的发展。
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