The Department of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
J Arthroplasty. 2011 Oct;26(7):1050-6. doi: 10.1016/j.arth.2011.05.007. Epub 2011 Jul 28.
This preclinical in vivo screening study compared bone graft incorporation and stem subsidence in cemented hemiarthroplasty after femoral impaction bone grafting with either morselized allograft bone (n = 5, control group) or a 1:1 mix of allograft and porous hydroxyapatite ceramics (HA) granules (n = 5, HA group). At 14 weeks, there was excellent bone graft incorporation by bone, and the stems were well fixed in both groups. The median subsidence at the cement-bone interface, measured using radiostereometric analysis, was 0.14 and 0.93 mm in the control and HA groups, respectively. The comparable histologic results between groups and good stem fixation in this study support the conduct of a larger scale investigation of the use of porous HA in femoral impaction bone grafting at revision hip arthroplasty.
本临床前体内筛选研究比较了股骨挤压植骨后骨水泥半髋关节成形术中同种异体骨碎骨移植（n = 5，对照组）和同种异体骨与多孔羟基磷灰石陶瓷（HA）颗粒 1:1 混合（n = 5，HA 组）的骨移植物结合和干细胞下沉情况。14 周时，两组均有良好的骨移植物骨结合，且柄均固定良好。使用放射立体分析测量的骨水泥-骨界面的中位下沉量，对照组和 HA 组分别为 0.14 和 0.93 毫米。组间可比的组织学结果和本研究中良好的柄固定支持对多孔 HA 在翻修髋关节置换术中股骨挤压植骨中的应用进行更大规模的研究。
