Research Laboratory LR99ES11, Biochemistry Department, Rabta University Hospital, Tunis, Tunisia.
Cytokine. 2011 Nov;56(2):338-42. doi: 10.1016/j.cyto.2011.06.026. Epub 2011 Jul 28.
To evaluate the effect of menopausal status and body mass index (BMI) on circulating leptin and adiponectin concentrations and investigate whether there is an influence of menopausal transition on the relationships of these adipokines and leptin to adiponectin (L/A) ratio with lipid profile and insulin resistance in a sample of Tunisian women. One hundred ninety-six premenopausal (mean age 35.3±7.6 years) and 180 postmenopausal women (mean age 53.4±6.2 years) were included in the study. Participants were stratified into obese and normal weight groups based upon their baseline BMI. Fasting glucose, HDL-cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), insulin, leptin, and adiponectin concentrations were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Premenopausal women had significantly higher leptin and L/A ratio and lower adiponectin levels than postmenopausal women. Menopause had no effect on the mean values of BMI, insulin or HOMA-IR, HDL-C, and TG. Using a multiple linear regression model, menopausal status was identified, as significant independent predictor for leptin and adiponectin levels. Irrespective of the menopausal status, obese women exhibited higher leptin and L/A ratio and lower adiponectin levels compared to those with normal weight. Comparison between the two menopausal stages in obese and normal weight groups showed that leptin and L/A ratio decreased, while adiponectin increased from pre- to postmenopausal stage only in obese group. The L/A ratio correlated better with lipid profile and HOMA-IR in postmenopausal stage. The present study showed a significant interaction between menopause and BMI on leptin and adiponectin secretion. Menopausal transition affects the relationships of these adipokines with lipids and insulin resistance.
为了评估绝经状态和体重指数（BMI）对循环瘦素和脂联素浓度的影响，并研究绝经过渡是否会影响这些脂肪因子与脂联素（L/A）比值与血脂谱和胰岛素抵抗的关系，我们对一组突尼斯女性进行了研究。研究纳入了 196 名绝经前女性（平均年龄 35.3±7.6 岁）和 180 名绝经后女性（平均年龄 53.4±6.2 岁）。根据基线 BMI 将参与者分为肥胖组和正常体重组。测量了空腹血糖、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、总胆固醇（TC）、胰岛素、瘦素和脂联素浓度。计算了胰岛素抵抗的稳态模型评估（HOMA-IR）。绝经前女性的瘦素和 L/A 比值较高，脂联素水平较低，而绝经后女性则相反。绝经对 BMI、胰岛素或 HOMA-IR、HDL-C 和 TG 的平均值没有影响。使用多元线性回归模型，确定了绝经状态是瘦素和脂联素水平的显著独立预测因子。无论绝经状态如何，肥胖女性的瘦素和 L/A 比值较高，脂联素水平较低，与正常体重女性相比。在肥胖和正常体重组中比较两个绝经阶段发现，只有在肥胖组中，从绝经前到绝经后阶段，瘦素和 L/A 比值降低，而脂联素增加。L/A 比值与绝经后阶段的血脂谱和 HOMA-IR 相关性更好。本研究表明，绝经和 BMI 之间存在显著的相互作用，影响瘦素和脂联素的分泌。绝经过渡会影响这些脂肪因子与脂质和胰岛素抵抗的关系。
