PG Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, India.
Eur J Med Chem. 2011 Sep;46(9):4366-73. doi: 10.1016/j.ejmech.2011.07.007. Epub 2011 Jul 12.
Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity.
新型三环咔唑 4a-k 是通过在浓盐酸和环己酮存在下的环转化，以 sydnone 衍生物 3a-k 为掩蔽肼一锅法合成的。对标题化合物进行了抗结核、抗癌、DNA 切割、抗氧化活性筛选。评估了 MIC、GI50、LC50、TGI。标题化合物表现出显著的抗结核、DNA 切割和抗氧化活性以及部分抗癌活性。
