Division of Emergency Medicine, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.
Am J Emerg Med. 2012 Sep;30(7):1320.e5-7. doi: 10.1016/j.ajem.2011.05.013. Epub 2011 Jul 29.
Synthetic cannabinoids have been popular recreational drugs of abuse for their psychoactive properties. Five of the many synthetic cannabinoids have been recently banned in the United States because of their unknown and potentially harmful adverse effects. Little is known about these substances. They are thought to have natural cannabinoid-like effects but have different chemical structures. Adverse effects related to synthetic cannabinoids are not well known. We provide clinical effects and patient outcome following K9 use. In addition, we briefly review synthetic cannabinoids. We present a 17-year-old adolescent boy with chest pain, tachycardia, and then bradycardia associated with smoking K9. Two synthetic cannabinoids, JWH-018 and JWH-073, were confirmed on laboratory analysis. In addition to the limited current data, we demonstrate harmful adverse effects related to toxicity of 2 synthetic cannabinoids. Further studies are needed.
合成大麻素因其致幻特性而成为流行的娱乐性滥用药物。由于其未知的潜在有害副作用，最近美国已经禁止了其中的五种合成大麻素。这些物质知之甚少。它们被认为具有类似天然大麻的作用，但化学结构不同。与合成大麻素相关的不良反应尚不清楚。我们提供 K9 使用后的临床效果和患者预后。此外，我们简要回顾了合成大麻素。我们介绍了一名 17 岁的青少年男性，他在吸烟 K9 后出现胸痛、心动过速，随后出现心动过缓。实验室分析证实存在两种合成大麻素，即 JWH-018 和 JWH-073。除了目前有限的数据外，我们还证明了与 2 种合成大麻素毒性相关的有害不良反应。需要进一步研究。
