Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Curr Opin Immunol. 2011 Oct;23(5):692-7. doi: 10.1016/j.coi.2011.07.004. Epub 2011 Jul 28.
Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC. Findings related to MDSC accumulation, activation, and mechanisms utilized in immune suppression are presented. Further, we discuss recent reports that suggest MDSC are expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.
髓系来源的抑制细胞（MDSC）是一种异质性的造血细胞前体群，能够在多种炎症环境中抑制免疫反应。在这里，我们回顾了最近的研究，详细描述了表型和功能不同的 MDSC 的扩增。介绍了与 MDSC 积累、激活和免疫抑制中使用的机制相关的发现。此外，我们还讨论了最近的报告，表明 MDSC 在移植过程中扩增，并且 MDSC 的调节可以参与预防移植物排斥。
