INSERM, UMR-S 1064, Nantes, France.
Front Immunol. 2012 Jul 17;3:208. doi: 10.3389/fimmu.2012.00208. eCollection 2012.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses in infection, chronic inflammation, cancer, and autoimmunity. In this paper, we review recent findings detailing their mode of action and discuss recent reports that suggest that MDSC are also expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection as well as graft-versus-host disease.
髓源性抑制细胞（MDSC）是一种异质性的未成熟造血前体细胞群，已知其在感染、慢性炎症、癌症和自身免疫中抑制免疫反应。在本文中，我们回顾了最近的发现，详细说明了它们的作用模式，并讨论了最近的报告，表明 MDSC 在移植过程中也会扩增，而 MDSC 的调节可以参与预防移植物排斥和移植物抗宿主病。
