Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606–8507, Japan.
Adv Drug Deliv Rev. 2011 Sep 16;63(12):988-99. doi: 10.1016/j.addr.2011.06.018. Epub 2011 Jul 23.
When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation.
当人工材料与血液接触时，会引起各种生物反应。为了成功开发用于将暴露于血液中的生物医学设备的生物材料，理解和控制这些相互作用是至关重要的。表面等离子体共振（SPR）光谱学是一种用于监测生物相互作用的表面敏感光学方法。SPR 能够实时和原位分析与生物材料研究相关的界面事件。在这篇综述中，我们描述了 SPR 生物传感器及其在监测补体在生物材料表面上的激活中的应用。我们还讨论了材料表面性质对补体激活的影响。
