Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Cardiol Clin. 2011 Aug;29(3):461-77. doi: 10.1016/j.ccl.2011.06.002.
Exercise intolerance is the primary symptom of chronic diastolic heart failure. It is part of the definition of heart failure and is intimately linked to its pathophysiology. Further, exercise intolerance affects the diagnosis and prognosis of heart failure. In addition, understanding the mechanisms of exercise intolerance can lead to developing and testing rational treatments for heart failure. This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure.
运动不耐受是慢性舒张性心力衰竭的主要症状。它是心力衰竭定义的一部分,与心力衰竭的病理生理学密切相关。此外,运动不耐受影响心力衰竭的诊断和预后。此外,了解运动不耐受的机制可以导致开发和测试心力衰竭的合理治疗方法。本文重点介绍运动生理学的基本原理,以及舒张性心力衰竭患者运动不耐受的评估、病理生理学和潜在治疗方法。