Kitzman Dalane W, Groban Leanne
Section of Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Heart Fail Clin. 2008 Jan;4(1):99-115. doi: 10.1016/j.hfc.2007.12.002.
Exercise intolerance is the primary symptom of chronic diastolic heart failure. It is part of the definition of heart failure and is intimately linked to its pathophysiology. Further, exercise intolerance affects the diagnosis and prognosis of heart failure. In addition, understanding the mechanisms of exercise intolerance can lead to developing and testing rational treatments for heart failure. This article focuses on the fundamental principles of exercise physiology and on the assessment, pathophysiology, and potential treatment of exercise intolerance in diastolic heart failure.
运动不耐受是慢性舒张性心力衰竭的主要症状。它是心力衰竭定义的一部分,与心力衰竭的病理生理学密切相关。此外,运动不耐受会影响心力衰竭的诊断和预后。另外,了解运动不耐受的机制有助于开发和测试针对心力衰竭的合理治疗方法。本文重点关注运动生理学的基本原理以及舒张性心力衰竭中运动不耐受的评估、病理生理学和潜在治疗方法。