Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China.
Asian Pac J Trop Med. 2011 Jul;4(7):547-9. doi: 10.1016/S1995-7645(11)60143-0.
To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.
Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.
Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).
The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
探讨 Runx3 蛋白和 TGF-β（1）在肠易激综合征（IBS）发病机制中的作用，以及这两种蛋白的相关性。
收集 IBS 患者和正常人的结肠组织，采用免疫组织化学方法检测 Runx3 蛋白和 TGF-β（1）在结肠中的表达，采用半定量分析方法对这两种蛋白的染色程度进行评价。
与对照组相比，IBS 患者的结肠 Runx3 蛋白和 TGF-β（1）表达没有变化（P>0.05）。有趣的是，IBS 患者的 Runx3 蛋白和 TGF-β（1）之间存在显著相关性（P<0.05）。
Runx3 蛋白和 TGF-β（1）在 IBS 发病机制中的作用有待进一步研究。
