肠易激综合征发病机制中的基因多态性。
Genetic polymorphism in pathogenesis of irritable bowel syndrome.
作者信息
Cheung Cynthia K Y, Wu Justin C Y
机构信息
Cynthia KY Cheung, Justin CY Wu, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
出版信息
World J Gastroenterol. 2014 Dec 21;20(47):17693-8. doi: 10.3748/wjg.v20.i47.17693.
Abstract
Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to ROME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS.
摘要
肠易激综合征（IBS）是一种基于症状的复杂疾病，尚无明确的生物标志物或公认的病理生理学机制。IBS是一种常见的功能性胃肠疾病，根据罗马Ⅲ标准，其定义为反复出现的腹痛或不适，在过去3个月中每月至少有3天出现以下至少两种症状：排便后缓解、发作与排便频率改变相关或发作与大便外观或形态改变相关。最近的研究发现，特定细胞因子和神经肽的基因多态性可能会影响IBS患者症状的发生频率和严重程度以及治疗反应。本文综述了基因测定如何影响IBS的临床表现、治疗反应及潜在生物标志物。
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