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膈疝住院患者的患病率、结局和风险-效益分析:对国家住院患者样本数据库的考察。

Prevalence, outcomes, and a risk-benefit analysis of diaphragmatic hernia admissions: an examination of the National Inpatient Sample database.

机构信息

Division of Thoracic Surgery, Department of Public Health, New York Presbyterian Hospital System, New York, NY 10065, USA.

出版信息

J Thorac Cardiovasc Surg. 2011 Oct;142(4):747-54. doi: 10.1016/j.jtcvs.2011.06.038. Epub 2011 Jul 30.

Abstract

OBJECTIVE

Current practice is to repair uncomplicated diaphragmatic hernias (UDHs) to avoid complications such as obstruction or gangrene. However, practice patterns are based on limited data. We analyzed the National Inpatient Sample to compare outcomes of patients with obstructed (ODH) or gangrenous (GDH) diaphragmatic hernias and those who underwent repair of UDHs to perform a risk-benefit analysis of observation versus elective repair.

PATIENTS AND METHODS

We queried the National Inpatient Sample for hospitalized patients who underwent a UDH repair as the principal procedure during their admission. To this repair group, we compared the outcomes of those patients who had a diagnosis of GDH or ODH. A risk-benefit analysis of observation versus elective repair was performed based on these data.

RESULTS

Over a 10-year period, 193,554 admissions for the diagnosis of diaphragmatic hernia were identified. A UDH was the diagnosis in 161,777 (83.6%) admissions with 38,764 (24.0%) admissions for elective repair. ODH or GDH was the reason for admission in 31,127 (16.1%) and 651 (0.3%), respectively. Compared with patients who underwent elective repair, mortality was higher in patients with ODH or GDH (1% vs 4.5%; P < .001; and 1% vs 27.5%; P < .001). Risk-benefit analysis suggested a small but real benefit to elective repair in patients aged 50 to 70 years or if the operative mortality is 1% or less.

CONCLUSIONS

Elective UDH repair is associated with better outcomes than admissions for ODH or GDH with a favorable risk-benefit profile than observation if the operative mortality is low.

摘要

目的

目前的治疗原则是修复单纯性膈疝(UDH),以避免梗阻或坏疽等并发症。然而,临床实践是基于有限的数据。我们分析了国家住院患者样本,比较了梗阻性膈疝(ODH)或坏疽性膈疝(GDH)患者与接受 UDH 修复患者的结局,以对观察与择期修复的风险效益进行分析。

患者和方法

我们查询了国家住院患者样本,以确定在住院期间主要接受 UDH 修复的住院患者。我们将这些患者与那些患有 GDH 或 ODH 诊断的患者进行比较。基于这些数据,我们对观察与择期修复进行了风险效益分析。

结果

在 10 年期间,共确定了 193554 例膈疝住院诊断。UDH 是 161777 例(83.6%)住院患者的诊断,其中 38764 例(24.0%)为择期修复。ODH 或 GDH 是 31127 例(16.1%)和 651 例(0.3%)住院的原因。与接受择期修复的患者相比,ODH 或 GDH 患者的死亡率更高(1% vs. 4.5%;P <.001;1% vs. 27.5%;P <.001)。风险效益分析表明,对于 50 至 70 岁的患者或手术死亡率为 1%或更低的患者,择期修复具有较小但真实的获益。

结论

与 ODH 或 GDH 入院相比,择期 UDH 修复与更好的结局相关,并且如果手术死亡率低,则与观察相比具有更有利的风险效益比。

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