Division of Allergy/Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07101-1709, USA.
J Neuroimmunol. 2011 Sep 15;238(1-2):73-80. doi: 10.1016/j.jneuroim.2011.07.001. Epub 2011 Jul 30.
Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N=30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf+GI, N=19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N=28) and normal (N=26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf+GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf+GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
研究了表现出感染和其他免疫损伤后行为症状波动的 ASD 儿童（ASD/Inf，N=30）的固有/适应性免疫反应和外周血单核细胞的转录谱。具有持续性胃肠道症状的 ASD/Inf 儿童（ASD/Inf+GI，N=19）与 ASD/no-Inf（N=28）和正常对照（N=26）相比，固有免疫刺激下促炎和抗炎细胞因子的产生较少，单核细胞的转录谱也有明显变化。这包括趋化因子（CCL2 和 CCL7）的 4-5 倍上调，与 ASD/Inf+GI 细胞产生更多的 CCL2 一致。这些结果表明 ASD/Inf+GI 儿童的固有免疫防御失调，使他们更容易受到常见微生物感染/失调和随后行为变化的影响。
